Clinical and biological implications of CD133-positive and CD133-negative cells in glioblastomas
نویسندگان
چکیده
منابع مشابه
Epigenetic regulation of CD133 and tumorigenicity of CD133 positive and negative endometrial cancer cells
BACKGROUND Recent data provide significant evidence to support the hypothesis that there are sub-populations of cells within solid tumors that have an increased tumor initiating potential relative to the total tumor population. CD133, a cell surface marker expressed on primitive cells of neural, hematopoietic, endothelial and epithelial lineages has been identified as a marker for tumor initiat...
متن کاملExpansion of CD133-positive glioma cells in recurrent de novo glioblastomas after radiotherapy and chemotherapy.
OBJECT Recent evidence suggests that a glioma stem cell subpopulation may determine the biological behavior of tumors, including resistance to therapy. To investigate this hypothesis, the authors examined varying grades of gliomas for stem cell marker expressions and histopathological changes between primary and recurrent tumors. METHODS Tumor samples were collected during surgery from 70 pat...
متن کاملCD133 Expression and Identification of CD133/nestin Positive Cells in Rhabdomyosarcomas and Rhabdomyosarcoma Cell Lines
BACKGROUND Co-expression of CD133, cell surface glycoprotein, and nestin, an intermediate filament protein, was determined to be a marker of neural stem cells and of cancer stem cells in neurogenic tumors. METHODS We examined the expression of CD133 and nestin in ten tumor tissue samples taken from patients with rhabdomyosarcomas and in five rhabdomyosarcoma cell lines. Immunohistochemistry a...
متن کاملCD133 negative cancer stem cells in glioblastoma.
Glioblastomas (GBM) are paradigmatic for the investigation of cancer stem cells (CSC) in solid tumors. Recently, the discovery of CD133- CSC in addition to CD133+ CSC has substantially added to our understanding of the complexity of GBM CSC. This review gives an overview on our current knowledge on CD133- cells in GBM and describes five different hypothesizes on the nature of CD133- cells in GB...
متن کاملExpression of CD133 in endometrial cancer cells and its implications
Cancer stem cells are an attractive therapeutic target for cancer. The present study examined stem cell characteristics of CD133+ cells isolated from endometrial cancer. Phenotypic characteristics, proliferation, migration, anchorage-independent growth, chemoresistance, gene expression profile and tumorigenicity of CD133+ tumor cells were assessed. Primary tumor exhibited immunoreactivity for C...
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ژورنال
عنوان ژورنال: Laboratory Investigation
سال: 2008
ISSN: 0023-6837,1530-0307
DOI: 10.1038/labinvest.2008.57